Capturing Ion Channel Gating
نویسندگان
چکیده
منابع مشابه
Capturing Ion Channel Gating
This is a golden age for ion channels: a time when chemistry, molecular biology, and electrophysiology have come together with structural biology to provide glimpses into some truly amazing membrane proteins. And yet, as usual, the answers yield more questions. Is a new structure the structure of an open channel or of a closed one? How does the voltage sensor actually move? Though providing ama...
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Three-dimensional images of the open state of the nicotinic acetylcholine receptor have been obtained at 9 A resolution. Comparison with the closed state reveals the structural basis of channel gating.
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An anomalous diffusion model for ion channel gating is put forward. This scheme is able to describe nonexponential, power-law-like distributions of residence time intervals in several types of ion channels. Our method presents a generalization of the discrete diffusion model by Millhauser, Salpeter, and Oswald [Proc. Natl. Acad. Sci. U.S.A. 85, 1503 (1988)] to the case of a continuous, anomalou...
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Stochastic models of ion channel gating date back as far as the pioneering work of Hodgkin and Huxley (1952), whose gating variables are often interpreted as probabilities. Sakmann and Neher directed the efforts that led to the first single-channel recordings, for which they won the Nobel Prize in Physiology and Medicine in 1991. Single-channel recordings (Sakmann and Neher, 1995) demonstrate t...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2004
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.200409209